TABLE 1.
Regression analyses of change in SF-LDQOL predicted by the changes in HADS-Depression and HADS-Anxiety from baseline to week 6 (N=145)a
| Predictors | β (95% CI) | t Value | p |
|---|---|---|---|
| Age at baseline | 0.00 (−0.16, 0.17) | 0.01 | 0.994 |
| MELD-Na score at baseline | −0.19 (−0.49, 0.11) | −1.28 | 0.204 |
| Ascites | 1.53 (−4.37, 7.43) | 0.51 | 0.609 |
| HE | −3.81 (−7.76, 0.13) | −1.91 | 0.058 |
| Alcohol-associated cirrhosis | 1.40 (−2.01, 4.81) | 0.81 | 0.419 |
| Listed for transplant at enrollment | −1.94 (−5.50, 1.62) | −1.08 | 0.284 |
| HCC at enrollment | 5.13 (−0.52, 10.77) | 1.80 | 0.075 |
| CirCom score | −2.21 (−3.83, −0.59) | −2.70 | 0.008 |
| Change in HADS-Depression | −1.71 (−2.27, −1.15) | −6.06 | <0.001 |
| Age at baseline | 0.01 (−0.17, 0.19) | 0.11 | 0.915 |
| MELD-Na score at baseline | −0.18 (−0.49, 0.13) | −1.14 | 0.256 |
| Ascites | 1.64 (−4.52, 7.80) | 0.53 | 0.600 |
| HE | −4.04 (−8.23, 0.15) | −1.91 | 0.059 |
| Alcohol-associated cirrhosis | 1.27 (−2.40, 4.94) | 0.68 | 0.495 |
| Listed for transplant at enrollment | −2.71 (−6.50, 1.08) | −1.42 | 0.159 |
| HCC at enrollment | 3.93 (−2.00, 9.87) | 1.31 | 0.192 |
| CirCom score | −2.56 (−4.27, −0.85) | −2.96 | 0.004 |
| Change in HADS-Anxiety | −1.08 (−1.60, −0.55) | −4.04 | <0.0001 |
a
Unless specified. For the analysis of HADS-Depression, 134 patients were included due to the missingness in the HADS-Depression score (n = 3), MELD-Na score (n = 1), and SF-LDQOL score (n = 7). For the analysis of HADS-Anxiety, 135 patients were included due to the missingness in the HADS-Anxiety score (n = 2), MELD-Na score (n = 1), and SF-LDQOL score (n = 7).
Abbreviations: CirCom score, cirrhosis-specific comorbidity scoring system comorbidity score; HADS, Hospital Anxiety and Depression Scale; MELD-Na, Model for End-Stage Liver Disease-Sodium; SF-LDQOL, Short-Form Liver Disease Quality of Life.