Figure 2.

The pooled overall prevalence of gonadal toxicity. Forest plot of proportions and 95% confidence intervals (CI) for studies evaluating the prevalence of gonadal toxicity after central nervous system cancer treatments. Gonadal toxicity was defined as basal LH or FSH levels above the upper limit of the reference range and/or low AMH levels in women or low inhibin B in men, and/or azoo-/oligospermia. Squares for each study indicate the proportion, the size of the boxes indicates the weight of the study, and the horizontal lines indicate the 95% CI. The data in bold and diamond represent the pooled prevalence for post-treatment infertility and 95% CI. Overall estimates are shown in the fixed- and random-effect models.