Figure 5.

The pooled prevalence of preserved fertility by sex. Forest plot of proportions and 95% confidence intervals (CI) for studies evaluating the prevalence of preserved fertility in male (A) and female (B) central nervous system cancer survivors. Preserved fertility was defined as the absence of gonadal toxicity including primary/secondary amenorrhea, no central/primary/secondary hypogonadism, or panhypopituitarism. Squares for each study indicate the proportion, the size of the boxes indicates the weight of the study, and the horizontal lines indicate the 95% CI. The data in bold and diamond represent the pooled prevalence for post-treatment infertility in good prognosis patients and 95% CI. Overall estimates are shown in the fixed- and random-effect models.