TABLE 1.
Participant characteristics at Exam 7, time of plasma sample for inflammatory biomarker measurement.
| Brain MRI sample | Full sample | Female | Male |
|---|---|---|---|
| Sample size, n, n (%) | 646 | 338 | 308 |
| Female, n (%) | 338 (52.3 %) | —— | —— |
| Age, mean(range) | 61 (40, 88) | 61 (41, 85) | 60 (40, 88) |
| APOE ε2 carriers, n (%) | 101 (15.6%) | 56 (16.6%) | 45 (14.6%) |
| APOE ε4 carriers, n (%) | 142 (22.0%) | 78 (23.1%) | 64 (20.8%) |
| Attended college, n (%) | 507 (78.5%) | 254 (75.1%) | 253 (82.1%) |
| Current smoker, n (%) | 78 (12.1%) | 50 (14.8%) | 28 (9.1%) |
| BMI Kg/m2, mean (sd) | 28 (5) | 27 (5) | 28 (4) |
| SBP mmHg, mean (sd) | 125 (18) | 124 (19) | 126 (17) |
| DBP mmHg, mean (sd) | 74 (9) | 72 (9) | 75 (9) |
| Hypertension Rx, n (%) | 197 (30.5%) | 91 (26.9%) | 106 (34.4%) |
| Total cholesterol mg/dL, mean (sd) | 200 (37) | 207 (37) | 192 (35) |
| Triglycerides mg/dL, mean (sd) | 132 (76) | 129 (71) | 136 (82) |
| Lipid Rx, n (%) | 128 (19.8%) | 50 (14.8%) | 78 (25.3%) |
| Fasting blood glucose mg/dL, mean (sd) | 104 (27) | 99 (22) | 109 (30) |
| Type 2 diabetes Rx, n (%) | 32 (5.0%) | 13 (3.8%) | 19 (6.2%) |
| MMSE, median (IQR) | 29 (2) | 29 (1) | 29 (2) |
| parent with dementia Dx, n (%) | 145 (22.4%) | 71 (21.0%) | 74 (24.0%) |
| Incident dementia through 2022, n (%) | 65 (10.1%) | 34 (10.1%) | 31 (10.1%) |
| Blood cancer prevalent Exam 7, n (%) | 6 (0.9%) | 5 (1.5%) | 1 (0.3%) |
| Blood cancer through 2019, n (%) | 27 (4.2%) | 12 (3.6%) | 15 (4.9%) |
| Time difference between brain MRI and Exam 7, mean (sd) | 0.75 (0.77) | 0.74 (0.81) | 0.76 (0.74) |
Abbreviations: APOE, Apolipoprotein E; BMI, body mass index; DBP, diastolic blood pressure; IQR, interquartile range; MMSE, mini‐mental state examination; MRI, magnetic resonance imaging; Rx, prescription; SBP, systolic blood pressure; sd, standard deviation.