FIGURE 1.

Flow diagram indicating number of participants with data available for inclusion for each analysis. Timepoints refer to number of visits at which both exercise and biomarker data were collected. APP, amyloid precursor protein; CDR, Clinical Dementia Rating; CSF, cerebrospinal fluid; DIAN, Dominantly Inherited Alzheimer Network; EYO, estimated years from expected symptom onset; MRI, magnetic resonance imaging; PiB PET, Pittsburgh compound B positron emission tomography; SD, standard deviation