Skip to main content
. 2024 Sep 7;31(11):1658–1668. doi: 10.1038/s41417-024-00821-4

Fig. 2. Cav-1 regulates 4T1 growth and lung metastasis in vivo.

Fig. 2

4T1 cells were injected into the mammary pads of BALB/c mice. Tumor progression and lung metastasis were followed for 4 weeks: A Green arrow in the image showing delayed tumor growth in Cav-1 KO injected mice compared to WT 4T1 injected mice at the end of week 1; B comparative tumor area (length × width) at the end of weeks 2 and 3; C Graph showing relative tumor weight at the end of weeks 2 and 3; D Image showing visible metastatic lesions in the WT lungs at the end of week 4, which were not present in the Cav-1 KO cell-injected mice; E H&E staining of lungs, yellow arrows show metastatic foci in WT, but no metastasis was seen in Cav-1 KO cells injected lungs at different time points. Statistical analysis was performed using unpaired Student’s t-test *P < 0.05; ***P < 0.001.