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. 2024 Oct 30;9:100258. doi: 10.1016/j.jtauto.2024.100258

Fig. 2.

Fig. 2

Phenotypical and functional similarities between the IL-7-induced Tph-like (IL-7-Tph) cells and Tph cells in RA joint (RA-Tph cells). (A) Expression of surface molecules (ICOS, CD69, HLA-DR, CXCR3, and CCR6) on IL-7-Tph (n = 3) and RA-Tph cells (n = 3) are compared in histograms. Gray histograms indicate the staining with isotype controls. Graphs indicate the mean percentage of positive cells in PD-1high CD4 T cells (n = 3). (B) Representative dot plots of cytokine production by the IL-7-Tph and RA-Tph cells with (lower panels) or without (upper panels) stimulation with PMA and ionomycin are shown. Graphs indicate the mean percentage of cytokine positive cells in PD-1high CD4 T cells (n = 3). (C) Induction of plasmablasts (CD27+ CD38+) and IgG production from memory B cells cocultured with IL-7-Tph cells(n = 6). Representative dot plots of CD38 and CD27 expression on B cells are shown in left panels. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗∗p < 0.0001.