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. 2024 Oct 30;9:100258. doi: 10.1016/j.jtauto.2024.100258

Fig. 3.

Fig. 3

Gene expression analysis of the IL-7-Tph cells. (A) Heatmap showing hierarchical clustering by DEGs among sorted naïve CD4 T (n = 3), IL-7-Tph (n = 3), and RA-Tph cells (n = 3). (B) Venn diagrams showing the number of the upregulated genes overlapped in IL-7-Tph and RA-Tph cells compared to naive CD4 T cells. (C) Volcano plots showing DEGs between IL-7-Tph and naive CD4 (upper), RA-Tph and naive CD4 (middle), and IL-7-Tph and RA-Tph (lower) cells. (D) GSEA analysis showing the pathway of genes upregulated in (C). (E) Expression levels of MAF, PRDM1, and PRDM1/BCL6 ratio in IL-7-Tph and RA-Tph cells by qRT-PCR analysis (n = 5). ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001.