Fig. 4.

Proposed platform for longitudinal monitoring of GSH. (A) Study design for the proposed platform for longitudinal monitoring of GSH. (B) Longitudinal schedule, outlining specific time points for monitoring GSH levels using a specialized pulse sequence, such as MEGA-PRESS. The scheme involves to addresses to monitor GSH levels using specialized pulse sequence (like MEGA-PRESS) at various time points. (C) MRI scanner equipped suitable head coil for MRS data collection from human participants. (D) The raw data can be analyzed in an appropriate toolbox (e.g. KALPANA is utilized for MRS data processing, step (E)) Tissue segmentation (CSF: Cerebrospinal fluid, GM: grey matter, WM: white matter) as well as absolute quantitation of GSH using KALPANA. (F) Interference from the study