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. 2024 Nov 15;8:262. doi: 10.1038/s41698-024-00752-1

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 8 — a H&E staining(left), and spatial cluster distribution of section (middle) labeled by colors, and density plots of specific gene sets of spatial cluster (right) for HCC2, defined into different spatial blocks. b UMAP plot showing the cell subclusters of HCC2 (top) and other tissues (bottom), labeling in different colors. c Heatmap representing the expression of ecological niche genes of HCC recurrence at the full-length transcriptome, whole transcriptome, proteome, and single-cell RNA levels. d UMAP plot showing the distribution of ecological niche genes of HCC recurrence. e Spatial feature plots showing the distribution of the ecological niche genes of HCC recurrence in HCC2. f Immunohistochemical staining showing increased KRT8, KRT18, and KRT20 expressions in the resected tumors originated from the rapid recurrence HCC patients compared to the recurrence-free HCC patients, original magnification, ×200. See also Supplementary Fig. 5.