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Relationship between Gαq gene and endurance exercise and genetic obesity and skeletal muscle dysfunction. Gαq-RNAi in muscle and adipose tissue inhibits the Gαq mediated Gαq/Mhc, Gαq/Srl/MRCC-I, and Gαq/SOD pathways, leading to increased triglyceride accumulation in F1 Drosophila, inducing genetic obesity and further developing skeletal muscle dysfunction. This process can be blocked by endurance exercise.
