Table 3.
Primary and secondary outcomes for ED patients with sepsis
| Outcome | Intervention ED |
Control EDs |
Unadjusted Difference-in- Differences Analysis |
Adjusted Difference-in- Differences Analysis |
||||
|---|---|---|---|---|---|---|---|---|
| Preintervention (n = 2,384) | Postintervention (n = 2,075) | Preintervention (n = 2,976) | Postintervention (n = 2,716) | Change or Odds Ratio (95% CI) | P Value | Adjusted change or Odds Ratio (95% CI) | P Value | |
| Door-to-antimicrobial time, min, median (IQR) | 160 (114–219) | 146 (102–205) | 139 (102–176) | 140 (105–177) | −12.5 (−18.7, −6.4) | <0.001 | −12.8 (−18.6, −7.0) | <0.001 |
| Door-to-antimicrobial time ≤3 h, n (%) | 1,438 (60.3) | 1,410 (68.0) | 2,306 (77.5) | 2,125 (78.2) | OR = 1.34 (1.12, 1.59) | 0.001 | aOR = 1.37 (1.14, 1.64) | 0.001 |
| In-hospital mortality, n (%) | 113 (4.7) | 148 (7.1) | 149 (5.0) | 190 (7.0) | OR = 1.08 (0.77, 1.51) | 0.65 | aOR = 0.76 (0.53, 1.10) | 0.14 |
| Mortality, 30 d, n (%) | 201 (8.4) | 262 (12.6) | 280 (9.4) | 332 (12.2) | OR = 1.17 (0.91, 1.51) | 0.23 | aOR = 0.90 (0.68, 1.19) | 0.45 |
| Mortality, 1 yr, n (%) | 467 (19.6) | 483 (23.3) | 603 (20.3) | 628 (23.1) | OR = 1.05 (0.87, 1.27) | 0.60 | aOR = 0.85 (0.68, 1.05) | 0.13 |
| Hospital charges (US$1000s), median (IQR)* | 7.3 (3.6–14.3) | 15.0 (7.0–32.7) | 7.6 (3.8–14.7) | 15.2 (7.6–30.1) | +3.9 (+1.3, +6.6) | 0.003 | +0.3 (−1.4, +2.1) | 0.71 |
| Hospital length of stay, d, median (IQR) | 2.7 (1.0–5.0) | 3.0 (1.1–6.1) | 2.7 (1.1–4.8) | 2.9 (1.2–5.6) | +0.4 (−0.01, +0.8) | 0.097 | −0.1 (−0.4, +0.1) | 0.19 |
Definition of abbreviations: aOR = adjusted odds ratio; CI = confidence interval; ED = emergency department; IQR = interquartile range; OR = odds ratio.
*
Excludes 80 patients with missing data for hospital charges.