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. 2024 Nov 15;23:408. doi: 10.1186/s12933-024-02491-w

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Arg ADMA ratios in mice and NHP. Arg/ADMA ratios from blood samples taken at termination in ob/ob mice (A) as indicated. Normalized Arg/ADMA ratios in NHP (C). Arg/ADMA ratios were determined in blood samples taken before and after 5 weeks of treatment in all animals. Values obtained at 5 weeks were normalized to the baseline measure. Results from Bayesian statistics analysis together with the hypothesis are shown for mice (B) and NHP (D)