Table 1.
Single-cell transcriptomics studies in nephrology
| Article information | Method (s) | Disease/model | Tissue/cell type | Cell number |
|---|---|---|---|---|
| Park et al. (2018) [45] | ScRNA-seq | Healthy mouse | Kidney | 57,979 |
| Fu et al. (2019) [46] | ScRNA-seq | STZ-diabetic eNOS-/- mice | Glomerular cells | 829 |
| Dumas et al. (2020) [47] | ScRNA-seq | A hyperosmolarity model in vitro and dehydrated mice in vivo | renal endothelial cell | 40,662 |
| Chung et al. (2020) [48] | ScRNA-seq | Healthy mouse | Glomerular cells | 75,000 |
| Braun et al. (2021) [49] | ScRNA-seq | ccRCC | Human renal tumors | 164,722 |
| Krishna et al. (2021) [50] | ScRNA-seq | ccRCC | ICB-naïve and ICB-treated patients | 167,283 |
| Obradovic et al. (2021) [51] | ScRNA-seq | ccRCC | Human renal tumors | 200,000 |
| He et al. (2021) [52] | Smart-seq2 | Human living donor renal biopsies and mouse | Podocytes, glomerular endothelial cells, MCs and PECs | 4,332 |
| Pickering et al. (2021) [53] | ScRNA-seq | CMV | Kidney transplant recipients prior to viremia, acutely after viremia, and long-term post-CMV viremia and propensity-matched nonviremic | \ |
| Sheng et al. (2021) [54] | ScRNA-seq & GWAS | Human kidney | Cell-type-eQTLs | 60,661 |
| Li et al. (2022) [55] | ScRNA-seq | Fibrosis mouse | Kidney | 309,666 |
| Wu et al. (2022) [56] | SnRNA-seq & Bulk RNA-seq | db/db (Lepr−/−) | Kidney | 946,660 |
| Lu et al. (2022) [57] | ScRNA-seq | DKD rat model | 10 cell types such as immune cells | \ |
| Li et al. (2022) [58] | ScRNA-seq | RCC | Human renal tumors | 270,000 |
| Kong et al. (2022) [59] | ScRNA-seq | cABMR after renal transplantation | PBMCs | 39,285 |
| Rashmi et al. (2022) [60] | Mux-Seq | Kidney transplants | Human kidney biopsies | 50,275 |
| Lake et al. (2023) [61] | ScRNA-seq | Healthy and diseased kidneys | Kidney | 400,000 |
| McDaniels et al. (2023) [62] | SnRNA-seq | Kidney transplants | Kidney allograft biopsies | 41,893 |
| Wen et al. (2023) [63] | ScRNA-seq | Kidney transplants | Kidney transplantation biopsy cores | 81,139 |
| Aidan et al. (2024) [64] | ScRNA-seq | Kidney transplants | Human kidney transplant biopsies | 31,203 |
| Lu et al. (2024) [65] | ScRNA-seq | Kidney transplant recipients with COVID-19-induced ARDS | PBMCs | 23,980 |
Abbreviations: scRNA-seq single-cell RNA sequencing, Smart-seq2 Switching mechanism at 5’ end of the RNAtranscript sequencing2, GWAS Genome-Wide Association Studies, snRNA-seq single-nucleus RNA sequencing, Bulk RNA-seq bulk RNA sequencing, Mux-Seq Multiplexed droplet single-cell sequencing, STZ streptozotocin, eNOS endothelial nitric oxide synthase, ccRCC clear-cell renal cell carcinoma, CMV cytomegalovirus, DKD diabetic kidney disease, RCC renal cell carcinoma, cABMR chronic antibody-mediated rejection, PBMCs peripheral blood mononuclear cells