Table 2.

Exposure estimation of nicotine pouches. Metrics of nicotine analytics of all investigated nicotine pouch samples and resulting nicotine exposure after consumption of pouches based on an extraction ratio of 50 % of the total nicotine content considering single and multiple use consumption patterns. Scenario 1: 5 pouches/day, scenario 2: 20 pouches/day.

	Minimum	$5^{\mathit{th}}$ percentile	Mean	Median	${95}^{\mathit{th}}$ percentile	Maximum
Nicotine content [mg]	2.20	3.15	14.08	9.04	47.90	56.00
Consumption pattern
Single use [µg/kg bw]	16	23	101	65	342	400
Scenario 1 [µg/kg bw and day]	79	113	503	323	1711	2000
Scenario 2 [µg/kg bw and day]	314	450	2011	1291	6843	8000