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. 2024 Aug 22;8(20):5382–5399. doi: 10.1182/bloodadvances.2024013508

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Figure 1. — Common NKG2A noncoding SNPs are in positive LD and associate with NKG2A expression independent of HCMV serostatus. (A) NKG2A frequency and MFI in NK cells, CD8⁺ T cells, and Vδ2⁺ T cells from phenotyping of 204 healthy blood donors. (B) Common noncoding KLRC1 SNPs and LD analysis from genotyping of 204 donors. Positive LD shaded blue; negative LD shaded red. (C) NKG2A⁺ NK cell frequency and MFI stratified by NKG2A variant. (D) NKG2A⁺ NK cell frequency and MFI stratified by HCMV serostatus and SNP rs2734440 (440C refers to SNP rs2734440 C and 440T refers to rs2734440 T). (E) Correlation between NKG2A⁺ NK cell frequency and MFI in HCMV^– and HCMV⁺ individuals. (F) Distribution of rs2734440 alleles among different ethnic groups. For panels C-D, t tests were performed, and the mean ± standard error of the mean (SEM) was presented to analyze NKG2A frequencies. For panels A,C-D, Mann-Whitney tests were performed, and median ± interquartile range (IQR) is presented to analyze NKG2A MFI. Correlations were assessed using the Pearson correlation coefficient for panel E. LD was assessed using the χ² test for panel B. The symbols represent individual samples. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.

Figure 1. — Common NKG2A noncoding SNPs are in positive LD and associate with NKG2A expression independent of HCMV serostatus. (A) NKG2A frequency and MFI in NK cells, CD8⁺ T cells, and Vδ2⁺ T cells from phenotyping of 204 healthy blood donors. (B) Common noncoding KLRC1 SNPs and LD analysis from genotyping of 204 donors. Positive LD shaded blue; negative LD shaded red. (C) NKG2A⁺ NK cell frequency and MFI stratified by NKG2A variant. (D) NKG2A⁺ NK cell frequency and MFI stratified by HCMV serostatus and SNP rs2734440 (440C refers to SNP rs2734440 C and 440T refers to rs2734440 T). (E) Correlation between NKG2A⁺ NK cell frequency and MFI in HCMV^– and HCMV⁺ individuals. (F) Distribution of rs2734440 alleles among different ethnic groups. For panels C-D, t tests were performed, and the mean ± standard error of the mean (SEM) was presented to analyze NKG2A frequencies. For panels A,C-D, Mann-Whitney tests were performed, and median ± interquartile range (IQR) is presented to analyze NKG2A MFI. Correlations were assessed using the Pearson correlation coefficient for panel E. LD was assessed using the χ² test for panel B. The symbols represent individual samples. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.