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. 2024 Aug 22;8(20):5382–5399. doi: 10.1182/bloodadvances.2024013508

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© 2024 by The American Society of Hematology. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.

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Figure 2. — SNPs among KLR gene family members are in LD and associate with NKG2A expression. (A) KLR gene complex and SNPs targeted. (B) LD between selected NKG2C, NKG2D, and CD94 SNPs based on the genotyping of 204 healthy donors. Positive LD shaded blue; negative LD shaded red. (C) NKG2A frequency and MFI stratified by CD94 SNPs. (D) NKG2A MFI stratified by CD94 SNPs, in conjunction with NKG2A variants. (E) NKG2A⁺ NK cells frequency stratified by NKG2C SNPs and HCMV serostatus. (F) NKG2A MFI stratified by NKG2C SNPs and CD56 cell surface expression levels. (G) NKG2A MFI on CD56^dim NK cells stratified using NKG2D SNPs. For panels C-E, t tests were performed, and mean ± SEM is presented to analyze NKG2A frequencies. For panels C-D,F-G, Mann-Whitney tests were performed, and median ± IQRs are presented to analyze NKG2A MFI. LD was assessed using the χ² test for panel B. Symbols represent individual samples. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.

Figure 2. — SNPs among KLR gene family members are in LD and associate with NKG2A expression. (A) KLR gene complex and SNPs targeted. (B) LD between selected NKG2C, NKG2D, and CD94 SNPs based on the genotyping of 204 healthy donors. Positive LD shaded blue; negative LD shaded red. (C) NKG2A frequency and MFI stratified by CD94 SNPs. (D) NKG2A MFI stratified by CD94 SNPs, in conjunction with NKG2A variants. (E) NKG2A⁺ NK cells frequency stratified by NKG2C SNPs and HCMV serostatus. (F) NKG2A MFI stratified by NKG2C SNPs and CD56 cell surface expression levels. (G) NKG2A MFI on CD56^dim NK cells stratified using NKG2D SNPs. For panels C-E, t tests were performed, and mean ± SEM is presented to analyze NKG2A frequencies. For panels C-D,F-G, Mann-Whitney tests were performed, and median ± IQRs are presented to analyze NKG2A MFI. LD was assessed using the χ² test for panel B. Symbols represent individual samples. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.