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Article title
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Author
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Journal
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Year
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Summary
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Brief communication: duration of platelet dysfunction after a 7-day course of Ibuprofen
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Goldenberg et al. [13]
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Annals of Internal Medicine
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2005
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11 healthy adult volunteers received 600 mg ibuprofen orally every eight hours for seven days. Aggregometry showed increased closure time at 40 minutes, with some recovery at eight hours and some recovery at 24 hours
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Assessment of common nonsteroidal anti-inflammatory medications by whole blood aggregometry: a clinical evaluation for the perioperative setting
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Scott et al. [14]
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World Neurosurgery
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2014
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12 healthy volunteers received 600 mg ibuprofen three times per day or naproxen 440 mg twice a day for three days. After 24 hours, aggregometry showed no inhibition with ibuprofen while naproxen showed inhibition. At 48 hours, naproxen inhibition recovered in 83% of women and 50% of men. At 72 hours, all platelet function recovered
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Dose responses of ibuprofen on platelet aggregation and coagulation in human platelets in vitro
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Martini et al. [15]
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Military Medicine
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2016
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Blood samples collected from four healthy humans were dosed to reach 163 µg/mL ibuprofen or higher, reaching two times, four times, eight times, and sixteen times the initial concentration. Aggregometry showed increased closure time at 163 µg/mL using arachidonic acid activation and at two times concentration using collagen activation
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The interaction of ibuprofen and diclofenac with aspirin in healthy volunteers
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Schuijt et al. [16]
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British Journal of Pharmacology
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2009
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12 healthy volunteers received 50 mg diclofenac three times per day or 800 mg ibuprofen two times per day. After 8 hours, TxB2 titers were reduced by 30% with diclofenac and 83% with ibuprofen
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Platelet inhibitory effects of OTC doses of naproxen sodium compared with prescription dose naproxen sodium and low-dose aspirin
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Schiff et al. [17]
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Current Medical Research and Opinion
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2009
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48 volunteers received 220 mg two to three times per day versus 550 mg two times per day of naproxen and found similarly reduced (97%+ inhibition) titers of TxB2 compared to 81mg aspirin (98%+ inhibition) 24 hours after the last dose
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Effects of celecoxib, a novel cyclooxygenase-2 inhibitor, on platelet function in healthy adults: a randomized, controlled trial
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Leese et al. [18]
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Journal of Clinical Pharmacology
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2000
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24 healthy adults took 500 mg of naproxen twice per day. After 24 hours, both platelet aggregation and TxB2 titers were reduced
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Valdecoxib does not impair platelet function
|
Leese et al. [19]
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American Journal of Emergency Medicine
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2002
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62 Healthy volunteers were given either 500 mg naproxen or 75 mg diclofenac. After eight hours, aggregometry showed that patients who took diclofenac had normal platelet aggregation and patients who took naproxen had increased closure times. TxB2 titers were also measured at 8 hours and the diclofenac arm showed recovery while the naproxen arm showed significantly decreased measurements
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The impact of selective and non-selective non-steroid anti-inflammatory drugs on secondary hemostasis in healthy volunteers
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Schjerning et al. [20]
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Thrombosis Research
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2009
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20 healthy male volunteers received 250 mg naproxen for 21 days. 12 hours after each dose, platelet samples taken from the patients showed inhibition of aggregation
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Selective inhibition of COX-2 in humans is associated with less gastrointestinal injury: a comparison of nimesulide and naproxen
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Shah et al. [21]
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Gut
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2001
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36 healthy volunteers received 500 mg naproxen two times per day for 14 days. After one to two hours, TxB2 titers were reduced by 98% with partial recovery two days after the last dose. Platelet aggregation was inhibited with AA but less with ADP activation
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Effect of non-selective, non-steroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors on the PFA-100 closure time
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Blaicher et al. [22]
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Anaesthesia
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2004
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44 healthy volunteers received 75 mg diclofenac sodium. Aggregometry showed inhibition at three hours with complete recovery at 12 hours
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Comparison of the effect of intravenous ketoprofen, ketorolac and diclofenac on platelet function in volunteers
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Niemi et al. [23]
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Acta Anesthesiology Scandinavia
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1997
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10 healthy volunteers were given 1.1 mg/kg diclofenac intravenously. After 2 hours, inhibition was found with adrenaline activation with complete recovery by 24 hours. With ADP activation, no inhibition was found
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Propacetamol augments inhibition of platelet function by diclofenac in volunteers
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Munsterhjelm et al. [24]
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British Journal of Anesthesia
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2003
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10 healthy male volunteers received diclofenac intravenously to reach 1.1 mg/kg and found increased closure time at 30 minutes with complete recovery after 22–24 hours
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Effect of diclofenac sodium (feloran) on platelet aggregation
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Tyutyulkova et al. [25]
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Methods and Findings in Experimental and Clinical Pharmacology
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1984
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8 healthy volunteers received 25 mg diclofenac three times per day for eight days. 10 hours after the last dose, 25% inhibition was found
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Platelet function following administration of a novel formulation of intravenous diclofenac sodium versus active comparators: a randomized, single dose, crossover study in healthy male volunteers
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Bauer et al. [26]
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Journal of Clinical Anesthesiology
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2010
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30 healthy volunteers received diclofenac sodium intravenously (37.5 mg) or diclofenac potassium orally (50 mg). Aggregometry showed inhibition at 1.5 and 3 hours with near-complete recovery after 6 hours for both treatment arms
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Indomethacin prevents the long-lasting inhibitory effect of aspirin on human platelet cyclo-oxygenase activity
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Livio et al. [27]
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Prostaglandins
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1982
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3 volunteers received 50 mg indomethacin. After two hours, aggregometry showed inhibition, and TxB2 titers were reduced (99% inhibition) with recovery of both at 48 hours
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Time-dependent inhibition of platelet cyclo-oxygenase by indomethacin is slowly reversible
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Walenga et al. [28]
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Prostaglandins
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1986
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4 healthy adults received 25 mg indomethacin. After six hours, inhibition of TxB2 production was found with recovery by 24 hours
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Meloxicam, 15 mg/day, spares platelet function in healthy volunteers
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deMeijer et al. [29]
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Clinical Pharmacology & Therapeutics
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1999
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15 healthy volunteers took 25 mg indomethacin three times per day for seven days or 15 mg meloxicam one time per day for seven days. After one hour, aggregometry showed inhibition, and TxB2 titers were reduced (95%+ inhibition).
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A comparison of the effects of nabumetone vs meloxicam on serum thromboxane B2 and platelet function in healthy volunteers
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vanKraaij [30]
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British Journal of Pharmacology
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2002
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12 healthy volunteers received 50 mg indomethacin. After two hours, aggregometry showed inhibition, and TxB2 titers were reduced
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Effects of meloxicam on platelet function in healthy adults: a randomized, double-blind, placebo-controlled trial
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Rinder et al. [31]
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The Journal of Clinical Pharmacology
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2002
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82 healthy subjects received 75 mg indomethacin one time per day for eight days. After six hours, aggregometry showed inhibition and TxB2 titers were reduced
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Inhibition of human platelet function in vitro and ex vivo by acetaminophen
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Lages et al. [32]
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Thrombosis Research
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1989
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5 healthy volunteers received 650 or 1,000 mg acetaminophen. After one hour, inhibition of aggregation was not found while TxB2 titers showed 30–60% inhibition
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Influence on platelet aggregation of i.v. parecoxib and acetaminophen in healthy volunteers
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Munsterhjelm et al. [33]
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British Journal of Anesthesiology
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2006
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18 healthy volunteers received 1 g of acetaminophen intravenously. After 10 minutes, no inhibition of platelet aggregation nor a reduction of TxB2 titers was found. AA activation at 500 µM showed high variability but possible inhibition
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Dose-dependent inhibition of platelet function by acetaminophen in healthy volunteers
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Munsterhjelm et al. [34]
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Anesthesiology
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2005
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13 healthy males received acetaminophen intravenously to reach 30 mg/kg. With AA activation, increased closure time was found only at the 10-minute mark with recovering function by 90 minutes. Other activators of platelets found no inhibition
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Acetaminophen and meloxicam inhibit platelet aggregation and coagulation in blood samples from humans
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Martini [35]
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Blood Coagulation and Fibrinolysis
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2014
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Blood samples from six healthy humans were dosed to 214 µg/mL acetaminophen and found to increase closure time
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Point-of-care platelet function tests: detection of platelet inhibition induced by nonopioid analgesic drugs
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Scharbert et al. [36]
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Blood Coagulation and Fibrinolysis
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2007
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40 healthy volunteers received 75 mg diclofenac or 1,000 mg acetaminophen intravenously. After 30 minutes, diclofenac showed inhibition while acetaminophen showed no effect
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