Table 5.
Summarized key findings.
| Overall | CA-CNSI | HAVM | p-Value | |
|---|---|---|---|---|
| Age (as years, mean (SD)) | 54.1 (15.6) | 47.9 (16.2) | 59.9 (13.1) | 0.045 |
| Microbiology | 0.009 | |||
| Not identified* (n (%)) | 3 (11.1) | 0 (0.0) | 3 (21.4) | |
| Gram-positive (n (%)) | 12 (44.4) | 9 (69.2) | 3 (21.4) | |
| Gram-negative (n (%)) | 8 (29.6) | 1 (7.7) | 7 (50.0) | |
| Mixed flora (n (%)) | 4 (14.8) | 3 (23.1) | 1 (7.1) | |
| mRS at discharge | 0.525 | |||
| No symptoms (n (%)) | 0 (0.0) | 0 (0.0) | 0 (0.0) | |
| No significant disability (n (%)) | 1 (3.7) | 1 (7.7) | 0 (0.0) | |
| Slight disability (n (%)) | 4 (14.8) | 3 (23.1) | 1 (7.1) | |
| Moderate disability (n (%)) | 4 (14.8) | 2 (15.4) | 2 (14.3) | |
| Moderate-severe disability (n (%)) | 4 (14.8) | 1 (7.7) | 3 (21.4) | |
| Severe disability (n (%)) | 9 (33.3) | 3 (23.1) | 6 (42.9) | |
| Death (n (%)) | 5 (18.5) | 3 (23.1) | 2 (14.3) | |
| CSF- WBC at Diagnosis (median [25th percentile – 75th percentile]) | 682 [246 – 2′944] | 1181 [685 – 66′410] | 346 [176 – 1′819] | 0.221 |
| CSF-WBC at IVT Initiation (median [25th percentile – 75th percentile]) | 596 [69 – 1′920] | 511 [91 – 1′827] | 680 [76 – 2′659] | 0.606 |
Key findings from the comparisons between patients with community-acquired central nervous system infections (CA-CNSI) and healthcare-associated ventriculitis and meningitis (HAVM) are summarized in this table. mRS: modified Rankin scale. CSF- WBC: cerebrospinal fluid white blood cell count.