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Mechanical sensitivity, force (g) required for 50% threshold for paw withdrawal, as a function of time in CCI (A), SNI (B) and sham (C) rats. Mechanical paw-withdrawal thresholds of the ligated paw were significantly attenuated after ligation (indicated by an arrow) in the CCI and SNI models as compared to the right paw (control), and to sham. In both groups, increased mechanical sensitivity persisted for 24 days after ligation.
