Figure 6.

Survival of TCRV-infected mice treated with CpG ODN fma1555. Newborn Balb/c mice (1–4 days old) were infected with TCRV (2000 TC₅₀/mouse). (a) CpG ODN 1555 (50 μg/mouse IP) protects newborn mice from infection when administered at the time of infection (open squares, n = 9), but cannot protect mice if administered three days prior to infection (open triangles, n = 7). (b) CpG ODN fma1555 (50 μg/mouse) administration protected mice when administered three days prior to infection (open triangles, n = 8), but not when administered at the time of infection (open squares, n = 9). Control mice received ODN fma1556 lacking CpG motifs on day −3 (open diamonds, n = 6). (c) Combination of CpG ODN 1555 (25 μg/mouse) and CpG ODN fma1555 (25 μg/mouse) administered on day −3 (closed triangles, n = 10) or at the time of infection (closed squares, n = 11) extends the period of treatment against the disease.