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. 2005 Jun 21;33(11):3550–3560. doi: 10.1093/nar/gki657

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© The Author 2005. Published by Oxford University Press. All rights reserved

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Scheme 2 — Synthesis of the phosphinylating reagent 8 and preparation of deoxyribonucleoside phosphoramidites (1a–d) from suitably protected deoxyribonucleosides (9a–d). (i) bis(N, N-diisopropylamino)chlorophosphine, N,N-diisopropylethylamine, CH₂Cl₂, 25°C, 2 h; (ii) 8, 1H-tetrazole, MeCN, 25°C, 2–16 h; (iii) silica gel chromatography.