TABLE 1.
Parameter | Value for mice (mean ± SD)
|
|
---|---|---|
WT | KO | |
Whole blood | ||
WBC (103 cells/μl) | 7.9 ± 2.3 | 7.0 ± 2.3 |
RBC (106 cells/μl) | 11.0 ± 0.5 | 11.0 ± 0.3 |
Hb (g/dl) | 16.9 ± 0.5 | 16.5 ± 0.5 |
PLT* (109 cells/liter) | 1338 ± 78 | 966 ± 130 |
MPV (fl) | 6.8 ± 0.9 | 6.9 ± 1.3 |
PDW (%) | 49.0 ± 5.2 | 51.6 ± 9.4 |
Blood serum | ||
Sodium (mmol/liter) | 77.7 ± 1.7 | 81 ± 1.7 |
Potassium (mmol/liter) | 3.2 ± 0.1 | 2.8 ± 0.2 |
Chloride (mmol/liter) | 59 ± 1 | 61 ± 1.7 |
Urea** (mmol/liter) | 9.4 ± 1.5 | 7.2 ± 1.0 |
Creatinine | 0.04 ± 0.01 | 0.04 ± 0.01 |
Albumin (g/liter) | 41.7 ± 2.1 | 41 ± 3.0 |
Total bilirubin (μmol/liter) | 2.3 ± 0.6 | 2.7 ± 2.1 |
ALP (IU/liter) | 182 ± 24 | 207 ± 95 |
AST (IU/liter) | 79 ± 14 | 117 ± 18 |
CK (IU/liter) | 277 ± 180 | 247 ± 33 |
White cell count (WBC), red blood cell count (RBC), hemoglobin (Hb), platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), alkaline phosphatase (ALP), aspartate aminotransferase (AST), and creatine kinase (CK) values were determined. Values are for at least four mice except for ALP, AST, and CK, which are for two or more mice. *, P ≤ 0.0001; **, P ≤ 0.0003. WT, wild type; KO, knockout.