Figure 3. ET-1 receptor blockade impairs metabolic activity in HG-SOC cells.

(A) Lactate dehydrogenase (LDH) activity was measured in patient-derived HG-SOC cells stimulated for 48 h with ET-1 (100 nM) alone or with macitentan (1µM, MAC). Values are the mean ± SD. (B) The lactate content was measured in the secretome of HG-SOC cells stimulated as in A. Significance signifies ordinary one-way ANOVA P value with Tukey's multiple comparison test.