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Summary of the effects of CpG 1018 and AddaVax on the immunogenicity of different mHA vaccine platforms
| Unadjuvanted | CpG 1018-adjuvanted | AddaVax-adjuvanted | |
|---|---|---|---|
| mHA WIV Vaccine | High immunogenicity with Th1-biased immune response | Limited increase in in vivo cross-protection | Decrease in serum passive transfer cross-protection |
| mHA split vaccine | Moderate immunogenicity with Th2-biased immune response | Increase in in vivo cross-protection | Increase in serum passive transfer cross-protection |
