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Novel pharmacology produced through the heterooligomerization of the δ opioid receptor (DOP-R) and κ opioid receptor (KOP-R). The functional response to the binding of 6′-GNTI is different for the three forms of the opioid receptor presented: δ (A), κ (C), and δ–κ heteromer (B). Only the heteromeric complex (B) is capable of producing a robust response to the analgesic.
