Fig. 1. Manhattan plot based on the meta-analysis of normal tension glaucoma (NTG).

Each dot (N = 22) represents a single nucleotide polymorphism (SNP), and the red line represents the threshold for multiple testing correction (p < 5 × 10⁻⁸) and blue line p < 5 × 10⁻⁶; p-values derived from logistic regression models are two-sided. Previously unidentified loci are highlighted in purple and represented in the plot as red dots, while known loci are in black.