Table 1.
Database to predict LLPS formation
| Database | Function | Website | Reference |
|---|---|---|---|
| D2P2 | Prediction of disorder proteins | http://d2p2.pro | 22 |
| DrLLPS | Provide annotations of known and computationally detected LLPS-associated proteins, including IDR, post-translational modification, disease-associated information, etc. | http://llps.biocuckoo.cn/ | 23 |
| LLPSDB | Provide protein sequence, modifications on specific amino acids, ability of coalescing with nucleic acid, phase behavior, experimental conditions | http://bio-comp.org.cn/llpsdb | 24 |
| MloDisDB | Provide information on LLPS and related diseases | http://mlodis.phasep.pro/ | 25 |
| PhaSepDB | Provide annotation for phase separation (PS) entries, including the material states of the PS droplet, verification experiments, PS partners, mutations, modification, etc. | http://db.phasep.pro/ | 26 |
| PhaSePred | Provides self-assembling and partner-dependent phase-separating protein prediction, and integrates scores from several PS-related predicting tools. | http://predict.phasep.pro | 27 |
| PhaSePro | Provides information on the biophysical driving force, biological function and regulation of LLPS. | https://phasepro.elte.hu | 28 |
| Pi-Pi predictor | Predicts LLPS formation in a given sequence based on π-π interaction. | 10.7554/eLife.31486.021 | 30 |
| PLAAC | Search protein sequences to identify the prion-like domains | http://plaac.wi.mit.edu/ | 29 |
| PSPredictor | A sequence-based tool for the prediction of proteins with LLPS potential | http://www.pkumdl.cn/PSPredictor | 31 |