Table 7.
Reagents modulate LLPS
| Reagent | Function | Mechanism | Reference |
|---|---|---|---|
| Dextran | Crowding reagent | Crowding reagents to promote the formation of MLO | 3 |
| Ficoll | Crowding reagent | Crowding reagents to promote the formation of MLO | 3 |
| 1,6-Hexanediol (1,6-HD) | 1,6-HD is an inhibitor and indicator of phase separation | 1,6-HD disrupts LLPS by interfering the weak hydrophobic protein-protein or protein-RNA interactions. | 3 |
| Lipoamide and lipoic acid | Inhibit stress granule formation | Dissolve stress granule by affecting the kinetics of phase separation | 374 |
| Poly(ethylene glycol) | Crowding reagent | Crowding reagents to promote MLO | 3 |