TABLE 1.
Demographic, clinical, and laboratory characteristics of participants.
| Number of participants (n = 63) | ||||
|---|---|---|---|---|
| Sex (female) | 27 (43) | |||
| Age (years) | 24 ± 5 | |||
| BMI (kg/m2) | 22 (21–24) | |||
| Clinical and laboratory data of participants | ||||
|---|---|---|---|---|
| M1 | M2 | M3 | M4 | |
| Number of samples | 51 | 48 | 44 | 43 |
| pNfL (pg/mL) | 4.57 (3.34–6.39) | 4.58 (3.74–6.0) | 5.64 (4.46–8.04) | 6.53 (4.65–7.92) |
| pNfL increase (pg/mL) a | 0.095 (−0.875 to 0.519) | 0.164 (−1.117 to 1.614) | ||
| Total pNfL increase b | 1.70 (0.78–3.15) | |||
| NfL Z score | −0.28 (−1.28 to 0.67) | −0.28 (−0.88 to 0.50) | 0.45 (−0.28 to 1.29) | 0.74 (−0.18 to 1.17) |
| NfL Z score increase a | 0.16 (−0.38 to 0.50) | 0.08 (−0.43 to 0.50) | ||
| Total NfL Z score increase b | 1.00 (0.53–1.65) | |||
| LLS | 4 (2–5) | 2 (1–4) | ||
| Heart rate (bpm) | 80 (73–85) | 84 (76–92) b | 80 (73–86) | 84 (76–92) b |
| Heart rate increase c | 6 (−2 to 16) | 6 (−2 to 15) | ||
| SaO2 (%) | 98 (97–98) | 83 (79–87) b | 97 (97–98) | 83 (80–87) b |
| SaO2 decrease c | 14 (12–18) | 14 (11–16) | ||
Note: Data are depicted as median (IQR), mean ± standard deviation, and n (%), as appropriate. Demographic data were assessed at baseline. LLS was assessed according to Roach et al. (2018).
Abbreviations: bpm = beats per minute; LLS = Lake Louise Acute Mountain Sickness Score; M1–4 = measurements 1–4; pNfL = plasma neurofilament light; SaO2 = arterial oxygen saturation.
a
An increase/decrease of variables between M1/M2 and M3/M4, respectively.
b
An increase/decrease of variables between M1 and M4.
c
M2 and M4 of clinical parameters, that is, heart rate and SaO2 were performed after 3 h.