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. 2024 Oct 19;6(1):100373. doi: 10.1016/j.xhgg.2024.100373

Figure 4.

Figure 4

Greater immune infiltration in HCV tumor-adjacent tissue

(A and B) xCell immune deconvolution. (A) Comparison of the overall immune infiltration score in tumor and tumor-adjacent tissue segregated by etiology. (B) Comparison of CD8+ T cells in tumor and tumor-adjacent tissue segregated by etiology.

(C and D) quanTIseq immune deconvolution. (C) Comparison of M1 macrophages in tumor and tumor-adjacent tissue segregated by etiology, and (D) comparison of M2 macrophages in tumor and tumor-adjacent tissue segregated by etiology. For all boxplots, the bold line indicates the median, and the upper and lower limits of the boxes indicate the 75th and 25th percentiles, respectively. The lower and upper whiskers indicate the minimum and maximum. Dots outside of the box and whiskers indicate outliers. Significance tested between samples from the same etiology (HBV tumor:HBV tumor-adjacent and HCV tumor:HCV tumor-adjacent) or between samples from the same tissue (HBV tumor:HCV tumor and HBV tumor-adjacent:HCV tumor-adjacent) with Wilcoxon rank-sum tests.