FIGURE 2.

(a) Chevron plot of the X11 PDZ1‐PDZ2* construct (slow phase in black, fast phase recorded in refolding experiments in filled orange circles, fast phase recorded in unfolding experiments in empty orange circles) superimposed to the chevron plot of wild‐type X11 PDZ1‐PDZ2 (in gray). (b) Chevron plot of the X11 PDZ1‐PDZ2* construct (same color code as panel a) superimposed to the chevron plots obtained for the isolated PDZ1 (in red) and PDZ2* (in green). (c) Double mixing experiments performed to monitor the refolding of PDZ2* (blue circles) with the C‐terminal tail bound to a native PDZ1 (see text for details). The obtained k _obs are in agreement with those obtained in the unfolding of the X11 PDZ1‐PDZ2* tandem (empty orange circles).