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. 2024 Nov 18;33(12):e5203. doi: 10.1002/pro.5203

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© 2024 The Author(s). Protein Science published by Wiley Periodicals LLC on behalf of The Protein Society.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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(a) Alternative pathways for the folding and unfolding processes of the X11 PDZ1‐PDZ2 tandem, with microscopic and equilibrium rate constants of the reactions involved. (b) Global analysis of the chevron plots obtained for the X11 PDZ1‐PDZ2* construct (in black) and for PDZ1 and PDZ2 in isolation (in red and green, respectively). The system of equations used to fit data is described in detail in the text. (c, d) Simulations of folding and unfolding time course of X11 PDZ1‐PDZ2* at zero and high (6.8M) denaturant concentrations (see details in the text).