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. 2024 Oct 23;15(11):1843–1851. doi: 10.1021/acsmedchemlett.4c00269

Table 3. Effect of Cyclic Amine on Potency and In Vitro ADME Properties.

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a

Compounds 18, 21, 22, and 25 are racemates.

b

Data are the geometric mean of three independent experiments (n = 3) unless otherwise specified.

c

Permeability (Papp × 10–6 cm/s) as measured in PAMPA assay.

d

Half-life of compound incubated with rat (R), mouse (M), or human (H) liver microsomes (LM).

e

Data are from a single experiment (n = 1). N.D. = not determined.