. 2024 Oct 23;15(11):1843–1851. doi: 10.1021/acsmedchemlett.4c00269

Table 5. Binding Potencies of Key Compounds.

Compd	27	29	31
IRAK1 K_d (nM)^a	3.8	2.6	0.53
IRAK4 K_d (nM)^a	0.44	0.25	0.096
FLT3 K_d (nM)^a	<0.17	0.22	0.074
FLT3 (D835H) K_d (nM)^a	0.95	0.19	0.16
FLT3 (D835V) K_d (nM)^a	<0.17	<0.17	0.034
FLT3 (D835Y) K_d (nM)^a	1.1	0.20	0.10
FLT3 (ITD) K_d (nM)^a	2.3	<0.17	0.18
FLT3 (ITD, D835V) K_d (nM)^a	<0.17	<0.17	0.017
FLT3 (ITD, F691L) K_d (nM)^a	<0.17	<0.17	0.056
FLT3 (K663Q) K_d (nM)^a	0.72	1.6	1.5
FLT3 (N841I) K_d (nM)^a	0.81	0.58	0.24
FLT3 (R834Q) K_d (nM)^a	0.71	0.74	0.33

Data are the geometric mean of two independent experiments (n = 2).