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. 2024 Oct 23;15(11):1843–1851. doi: 10.1021/acsmedchemlett.4c00269

Table 6. Cellular Potencies of Key Compounds.

Compd 27 29 31
NanoBRET IRAK4 IC50 (nM)a 0.096 2.5 0.90
NanoBRET FLT3 IC50 (nM)a 2.2 51 1.7
NanoBRET FLT3 (D835Y) IC50 (nM)a 0.009 0.41 0.22
NF-κB (Pam3SCK4) IC50 (nM)b 3c 27 18
NF-κB (IL1B) IC50 (nM)b 6c 38 13
MOLM14 (D835Y) IC50 (nM)d 3 7e 7
MOLM14 (F691L) IC50 (nM)f 42 59 44
a

Data are the geometric mean of two independent experiments (n = 2).

b

Data are the geometric mean of three independent experiments (N = 3) unless otherwise specified.

c

Data are the geometric mean of four independent experiments (N = 4).

d

Data are the geometric mean of four independent experiments (N = 4) unless otherwise specified.

e

Data are the geometric mean of three independent experiments (N = 3).

f

Data are the geometric mean of two independent experiments (N = 2).