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. 2024 Nov 18;14(49):36794–36803. doi: 10.1039/d4ra06715k

Enzymatic Assay (EA) and binding constant (Ka) values of thiazole-linked coumarin piperazine hybrids (10a–i).

Compound % Inhibition (EA) Gal-1 Ka (104 M−1) Gal-3 Ka (10−6 M−1) LdPasea
10a 58.19 ± 1.12 8.8 NE NE
10b 25.93 ± 0.81 2.1 NE NE
10c 22.46 ± 1.67 4.1 NE NE
10d 56.73 ± 2.13 6.6 NE NE
10e 27.80 ± 0.76 6.5 NE NE
10f 80.57 ± 1.77 9.3 1.1 NB
10g 58.19 ± 3.28 9.8 1.0 NB
10h <10 NE NE NE
10i <10 NE NE NE
a

NE – not evaluated, NB – no binding.