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. 2024 Oct 24;67(21):19103–19120. doi: 10.1021/acs.jmedchem.4c01575

Figure 4.

Figure 4

(a) UV–vis spectra of trans-2 and (b) cis-2 solution in 1% v/v DMSO in PBS (6.5 μg/mL, 8.6 μM) irradiated with 365 and 530 nm light, respectively. A spectrum of trans-1 in PBS normalized to the same intensity at the 346 nm band maximum is given for comparison; (c) relative absorbance at 350 nm of 2 undergoing cyclic irradiation with 365 and 530 nm for up to 5 cycles (0.0125 mg/mL, 16.5 μM, 1% v/v DMSO). The irradiation times were 30 and 300 s, respectively, long enough to reach complete conversion; (d) first-order kinetic analysis of cis-2trans-2 thermal isomerization in pH 7.4 PBS containing 1% v/v DMSO.