Table 3.
Details of Glycemic Control And Insulin Therapy After Randomization.
| Variable | Total (N = 100) | Conventional (N = 50) | InsulinAPP (N = 50) | P |
|---|---|---|---|---|
| BG prior to randomization (mg/dL) | 171 ± 51 | 170 ± 52 | 172 ± 50 | .839 |
| Initial prescription | ||||
| Only correction scheme | 44 (44%) | 27 (54%) | 17 (34%) | .001 |
| Bolus-correction | 18 (18%) | 2 (4%) | 16 (32%) | - |
| Basal-plus | 23 (23%) | 18 (36%) | 5 (10%) | - |
| Basal-bolus | 15 (15%) | 3 (6%) | 12 (24%) | - |
| Total daily insulin dose (unit/day) | 25.8 ± 23.9 | 23.5 ± 25.4 | 28.1 ± 22.3 | .207 |
| Insulin to body weight ratio (unit/kg/day) | 0.34 ± 0.32 | 0.31 ± 0.33 | 0.38 ± 0.31 | .250 |
| NPH insulin dose (unit/day) | 24.8 ± 10.4 | 27.0 ± 12.2 | 22.1 ± 7.1 | .160 |
| Regular insulin dose (unit/day) | 16.4 ± 17.4 | 12.1 ± 16.6 | 20.6 ± 17.3 | .002 |
| Capillary glucose (mg/dL) | 177.9 ± 49.7 | 188.7 ± 54.4 | 167.2 ± 42.5 | .040 |
| Glycemic dispersion (%) | 23.3 ± 12.0 | 26.4 ± 12.2 | 20.2 ± 11.0 | .020 |
| Proportion of days with average GC on target (100-180 mg/dL) | 53 (53%) | 23 (46%) | 30 (60%) | .161 |
| Percentage of patient-days with any glucose >180 mg/dL (%) | 63.1 | 74.8 | 51.3 | .011 |
| Number of patients with hypoglycemia (<70 mg/dL) | 10 (10%) | 8 (16%) | 2 (4%) | .046 |
| Low food acceptance or fasting | 39 (39%) | 20 (40%) | 19 (38%) | .838 |
| Use of prandial insulin in patients with oral intake | 33/61 (54.1%) | 5/30 (16.7%) | 28/31 (90.3%) | .001 |
Data are presented as mean ± SD; or n (%); unless otherwise noted.
BG: blood glucose; GC: glycemic control; NPH: Neutral Protamine Hagedorn.