Table 2.
Primary outcomes | Baseline | 2 weeks | 4 weeks | 4 months | Group F (p value) | Time F (p value) | Group *Time (p value) |
---|---|---|---|---|---|---|---|
PSQI total score | 9.10 (0.000) | 853.07 (0.000) | 8.18 (0.000) | ||||
tDCS + rTMS | 16.20 ± 2.74 | 7.36 ± 1.61 | 6.27 ± 2.44 | 7.02 ± 1.70 | |||
sham tDCS + rTMS | 15.90 ± 2.73 | 8.42 ± 2.70 | 7.68 ± 2.89 | 8.12 ± 2.04 | |||
tDCS + sham rTMS | 15.78 ± 2.17 | 9.31 ± 2.28 | 8.78 ± 2.87 | 9.16 ± 2.21 | |||
Sleep quality | 5.92 (0.003) | 364.67 (0.000) | 8.54 (0.000) | ||||
tDCS + rTMS | 2.55 ± 0.50 | 0.79 ± 0.41 | 0.78 ± 0.41 | 0.86 ± 0.40 | |||
sham tDCS + rTMS | 2.18 ± 0.83 | 1.02 ± 0.59 | 1.00 ± 0.61 | 1.16 ± 0.51 | |||
tDCS + sham rTMS | 2.41 ± 0.57 | 1.20 ± 0.69 | 1.16 ± 0.73 | 1.37 ± 0.63 | |||
Sleep latency | 1.35 (0.263) | 339.10 (0.000) | 1.32 (0.269) | ||||
tDCS + rTMS | 2.54 ± 0.69 | 1.00 ± 0.47 | 0.96 ± 0.42 | 1.04 ± 0.33 | |||
sham tDCS + rTMS | 2.44 ± 0.67 | 1.22 ± 0.62 | 1.18 ± 0.56 | 1.16 ± 0.55 | |||
tDCS + sham rTMS | 2.53 ± 0.73 | 1.18 ± 0.68 | 1.14 ± 0.69 | 1.16 ± 0.54 | |||
Sleep duration | 6.96 (0.001) | 292.79 (0.000) | 5.48 (0.001) | ||||
tDCS + rTMS | 2.14 ± 1.07 | 0.41 ± 0.50 | 0.41 ± 0.49 | 0.80 ± 0.40 | |||
sham tDCS + rTMS | 2.50 ± 0.76 | 0.62 ± 0.81 | 0.64 ± 0.72 | 0.78 ± 0.62 | |||
tDCS + sham rTMS | 2.20 ± 0.80 | 1.02 ± 0.88 | 0.98 ± 0.81 | 1.14 ± 0.63 | |||
Sleep efficiency | 23.47 (0.000) | 234.17 (0.000) | 11.12 (0.000) | ||||
tDCS + rTMS | 2.27 ± 0.92 | 0.61 ± 0.62 | 0.61 ± 0.59 | 0.88 ± 0.54 | |||
sham tDCS + rTMS | 2.58 ± 0.70 | 0.76 ± 0.85 | 0.74 ± 0.75 | 1.04 ± 0.73 | |||
tDCS + sham rTMS | 2.37 ± 0.82 | 1.59 ± 0.78 | 1.57 ± 0.70 | 1.59 ± 0.57 | |||
Sleep disturbance | 0.30 (0.740) | 59.52 (0.000) | 1.16 (0.324) | ||||
tDCS + rTMS | 1.52 ± 0.60 | 1.00 ± 0.19 | 0.96 ± 0.27 | 1.00 ± 0.33 | |||
sham tDCS + rTMS | 1.56 ± 0.76 | 1.08 ± 0.44 | 1.06 ± 0.37 | 1.00 ± 0.35 | |||
tDCS + sham rTMS | 1.43 ± 0.50 | 1.00 ± 0.69 | 1.00 ± 0.63 | 1.12 ± 0.52 | |||
Sleep medication | 1.45(0.239) | 91.28 (0.000) | 4.39 (0.002) | ||||
tDCS + rTMS | 2.63 ± 0.95 | 2.73 ± 0.62 | 1.70 ± 0.99 | 1.48 ± 0.50 | |||
sham tDCS + rTMS | 2.38 ± 1.16 | 2.78 ± 0.55 | 2.06 ± 0.79 | 1.72 ± 0.45 | |||
tDCS + sham rTMS | 2.67 ± 0.55 | 2.55 ± 0.58 | 2.20 ± 0.78 | 1.75 ± 0.44 | |||
Daytime dysfunction | 2.15 (0.120) | 208.43 (0.000) | 2.55(0.050) | ||||
tDCS + rTMS | 2.55 ± 0.89 | 0.82 ± 0.43 | 0.84 ± 0.73 | 0.96 ± 0.33 | |||
sham tDCS + rTMS | 2.26 ± 1.07 | 0.94 ± 0.79 | 1.00 ± 0.76 | 1.26 ± 0.44 | |||
tDCS + sham rTMS | 2.18 ± 0.82 | 0.78 ± 0.64 | 0.75 ± 0.59 | 1.04 ± 0.34 |
PSQI Pittsburgh Sleep Quality Index. F and p for group effects. Significant results are highlighted (p < 0.05) in bold
The data are presented as mean ± standard deviation (SD)