Table 2.
HbA1c and Pump Data by HCL System.
| Total population | Medtronic 670G/770G | Control IQ | Omnipod 5 | P value | |
|---|---|---|---|---|---|
| (N = 176) | (N = 47) | (N = 74) | (N = 55) | ||
| HbA1c baseline | N = 163 | N = 45 | N = 65 | N = 53 | .12 |
| % | 7.4 (6.8, 8.2) | 7.6 (6.7, 8.4) | 7.5 (6.85, 8.35) | 7.1 (6.7, 7.75) | |
| mmol/mol | 57 (51, 66) | 60 (50, 68) | 58 (51, 68) | 54 (50, 61) | |
| HbA1c 30 to 90 days | N = 97 | N = 36 | N = 36 | N = 25 | .51 |
| % | 7.1 (6.5, 7.6) | 7.1 (6.8, 7.78) | 7 (6.4, 7.58) | 7.1 (6.5, 7.45) | |
| mmol/mol | 54 (48, 60) | 54 (51, 62) | 53 (46, 59) | 54 (48, 58) | |
| HbA1c 91 to 180 days | N = 130 | N = 41 | N = 56 | N = 33 | .02 |
| % | 7.02 (0.82) | 7.30 (0.70) | 6.96 (0.90) | 6.78 (0.74) | |
| mmol/mol | 53 (9) | 56 (7.7) | 53 (9.8) | 51 (8.1) | |
| Change in HbA1c 91 to 180 day | N = 120 | N = 39 | N = 49 | N = 32 | .04 |
| % | −0.4 (−1, 0.1) | −0.1 (−0.8, 0.3) | −0.6 (−1.1, −0.15) | −0.55 (−0.98, 0) | |
| mmol/mol | −4.4 (−10.9, 1.1) | −1.1 (−8.7, 3.3) | −6.6 (−12, −1.6) | −6 (−10.7, 0) | |
| 30-day pump data | |||||
| TDD (units) |
N = 158 46.27 (33.6, 67.0) |
N = 46 45.2 (33.1, 68.1) |
N = 57 41.98 (33.4, 71.2) |
N = 55 48.7 (33.4, 61.5) |
.92 |
| TDD (units/kg) |
N = 158 0.60 (0.21) |
N = 46 0.62 (0.22) |
N = 57 0.60 (0.22) |
N = 55 0.58 (0.21) |
.69 |
| Bolus count (#/day) |
N = 158 5.22 (2.23) |
N = 46 5.66 (1.83) |
N = 57 4.99 (2.46) |
N = 55 5.10 (2.28) |
.28 |
| Bolus override (%) |
N = 158 0 (0, 9.05) |
N = 46 0 (0, 2.5) |
N = 57 0 (0, 12) |
N = 55 3.7 (0, 19.2) |
.008 |
| Automated delivery (%) |
N = 158 94 (81.75, 98) |
N = 46 86.5 (65.5, 95) |
N = 57 93 (89, 97) |
N = 55 99 (89, 100) |
<.0001 |
| Basal insulin (units/day) |
N = 158 25.35 (17.8, 34.3) |
N = 46 24.9 (18, 37.2) |
N = 57 24.9 (15.3, 37.36) |
N = 55 25.6 (21.4, 31.6) |
.77 |
| 90-day pump data | |||||
| TDD (units) |
N = 158 47.04 (36.5, 68) |
N = 46 47.05 (33.5, 66.8) |
N = 57 47.18 (37.4, 73.2) |
N = 55 46.9 (39.5, 63.2) |
.92 |
| TDD (units/kg) |
N = 158 0.62 (0.21) |
N = 46 0.63 (0.22) |
N = 57 0.63 (0.21) |
N = 55 0.60 (0.19) |
.75 |
| Bolus count (#/day) |
N = 158 4.8 (3.8, 6.59) |
N = 46 5.65 (4.48, 6.5) |
N = 57 4.9 (3.55, 7.5) |
N = 55 4.5 (3.7, 5.2) |
.08 |
| Bolus override (%) |
N = 158 1.05 (0, 8.85) |
N = 46 1.2 (0, 2.8) |
N = 57 0 (0, 15.5) |
N = 55 3.1 (0, 39.1) |
.02 |
| Auto mode (%) |
N = 158 92.5 (78, 97.3) |
N = 47 80 (54, 89) |
N = 56 95 (89.3, 97.8) |
N = 55 95 (82, 100) |
<.0001 |
| Basal insulin (units/day) |
N = 158 29.2 (12.7) |
N = 46 29.33 (13.7) |
N = 57 28.41 (12.7) |
N = 55 29.91 (12.0) |
.82 |
| Change in TDD (units/kg) |
N = 114 0.013 (−0.028, 0.063) |
N = 39 −0.003 (−0.063, 0.046) |
N = 39 0.028 (−0.0003, 0.062) |
N = 36 0.022 (−0.022, 0.072) |
.19 |
| Change in basal dose (units/day) |
N = 157 0.79 (−3.48, 4.5) |
N = 45 0.3 (−3, 4.45) |
N = 57 −0.49 (−5.69, 2.88) |
N = 55 2.1 (−1.2, 7.4) |
.04 |
| Severe Hypoglycemia, N (%) | 5 (2.8) | 1 (2.1) | 2 (2.7) | 2 (3.6) | .90 |
| DKA, N (%) | |||||
| Ketosis w/o acidosis | 6 (3.4) | 3 (6.4) | 3 (4.1) | 0 (0) | .17 |
| Ketoacidosis | 8 (4.6) | 1 (2.1) | 3 (4.1) | 4 (7.3) | |
| Infusion site failure, N (%) | 25 (14.2) | 7 (14.9) | 14 (18.9) | 4 (7.3) | |
Categorical variables were reported as number (percentage) and analyzed using the chi-square test. Continuous variables with non-normal distribution were reported as median (lower quartile 25%, upper quartile 75%) and analyzed using Wilcoxon/Kruskal–Wallis tests unless otherwise noted. Continuous variables with normal distribution were reported as mean (standard deviation) and differences between groups were determined using a one-way ANOVA.
DKA, diabetic ketoacidosis; HCL, hybrid closed loop; TDD, total daily insulin; w/o, without.