Colonic Avpr1a expression is greater after ZYM exposure in C57BL/6NTac mice, but not C57BL/6J mice. (A) Avpr1a mRNA levels were measured in SAL or ZYM-treated BL/6J and BL/6NTac mice. A 2 (strain) × 2 (treatment) ANOVA confirmed a significant Strain × Treatment interaction (F [1, 16] = 5.664, P = .030) on colorectal Avpr1a expression. * Indicates significant interaction based on ANOVA, P < .05. (B) Avpr1a protein levels in isolated colons were higher in ZYM-treated BL/6NTac compared with ZYM-treated BL/6J mice. * Indicates significant independent samples t-test (t = 2.669, P < .05) (n = 5).