Table 1.

Prioritized Candidate Genes Identified by Comparing BL/6NTac and BL/6J Substrains

Gene Symbol	Gene Name	Pain/Nociception Types That Have Been Associated in Mice	Number of Differential Snps/Consequence (So Term)	Snp(s) Identification
Celsr1	Cadherin, EGF LAG 7-pass G-type receptor 1	Neuropathic pain	2 SNPs/intron variants	rs51978880 rs236675812
Clip3	CAP-GLY domain containing linker protein 3	Thermal nociception	1 SNP/intron variant	rs3148686
Aoah	Acyloxyacyl hydrolase	Pelvic pain	1 SNP	Not identified on Ensembl Gene Browser
Cacna2d1	Calcium channel, voltage-dependent, alpha2/delta subunit 1	Mechanosensation	1 SNP	Not identified on Ensembl Gene Browser
Avpr1a	Arginine-vasopressin receptor 1A	Capsaicin and formalin inflammatory pain; acetic acid abdominal pain	1 SNP/noncoding transcript exon variant	rs29348001

NOTE. Only genes where a SNP exists within the 5′ flanking region, exon, introns, or 3′ UTR were included, which were defined as the gene and the surrounding DNA sequence up to 18K nucleotides outside the coding sequence on Ensembl Gene Browser. Note that only Avpr1a has been associated with more than 1 type of pain.

Abbreviation: CAP-GLY, Cytoskeleton-Associated Proteins- glycine rich; EGF, epidermal growth factor; LAG, laminin A G-type; UTR, untranslated region.