Table A2.

Histological evaluation system—Dermal or panniculus inflammation.

Score Finding	0	1	2	3	4
Dermal inflammation:	None	Minimal	Mild	Moderate	Severe
Granulocyte cell presence	None	Minimal	Mild	Moderate	Severe
Mononuclear cell (lymphocytes +plasma cells) presence	None	Minimal	Mild	Moderate	Severe
Macrophages and giant cell presence	None	Minimal	Mild	Moderate	Severe
Necrosis in the wound area	Normal, no necrosis	Rare necrotic foci surrounded by macrophages	Minimal necrosis involving less than 25% of the wound area surrounded by macrophages Or Necrosis of epidermis adnexa and up to 10% upper dermis (depth of dermis)	Focal necrosis, involving 60% of the wound area Or Necrosis or sloughing of the epidermis. Adnexal necrosis. Necrosis of 10 to 25% depth of dermal necrosis	Complete wound area necrotic. Or Sloughing of the adnexal epidermis necrosis. More than 25% of death from dermal necrosis