Table 2.
Laboratory Indexes of Patients with COVID-19
| Total (n=126) | Non severe (n=90) | Severe (n=28) | Critical (n=8) | P value | |||
|---|---|---|---|---|---|---|---|
| N vs S | N vs C | S vs C | |||||
| Cell count | |||||||
| White blood cell count(× 109 cells per L) | 5.17(3.77–7.12) | 5.06(3.79–6.67) | 4.83(3.63–8.52) | 7.64(4.54–14.50) | 0.793 | 0.049 | 0.202 |
| Platelet count (×109 per L) | 170.5(133.3–220.3) | 174.5(147.3–223.3) | 147.0(121.0–189.8) | 162(117.8–245.5) | 0.012 | 0.707 | 0.493 |
| Neutrophil count (× 109 cells per L) | 3.72(2.39–5.30) | 3.47(2.29–4.85) | 3.98(2.64–7.40) | 5.98(3.88–9.20) | 0.109 | 0.007 | 0.209 |
| Lymphocyte count (× 109 cells per L) | 1.03(0.68–1.48) | 1.20(0.91–1.65) | 0.69(0.41–0.87) | 0.36(0.30–0.67) | <0.001 | <0.001 | 0.052 |
| Monocyte count (× 109 cells per L) | 0.33(0.24–0.45) | 0.34(0.26–0.46) | 0.30(0.18–0.40) | 0.27(0.20–0.59) | 0.029 | 0.240 | 0.924 |
| NLR | 3.40(1.91–5.99) | 2.58(1.72–4.19) | 6.47(3.28–13.37) | 12.07(8.30–21.69) | <0.001 | <0.001 | 0.062 |
| PLR | 170.8(122.8–247.7) | 153(109.5–210.5) | 210.4(167.6–336.9) | 450(346.5–540.2) | <0.001 | <0.001 | 0.011 |
| LMR | 3.20(2.36–4.27) | 3.60(2.55–4.64) | 2.69(1.48–3.35) | 1.36(1.07–3.03) | <0.001 | 0.006 | 0.305 |
| Nutrition and Coagulation index | |||||||
| Albumin (g/L) | 44.40(40.60–47.53) | 45.80(42.65–48.15) | 39.65(36.38–44.38) | 30.95(29.45–34.4) | <0.001 | <0.001 | <0.001 |
| Fibrinogen (g/L) | 3.62(2.78–4.91) | 3.40(2.67–4.25) | 4.71(3.72–5.74) | 5.14(2.92–6.07) | <0.001 | 0.051 | 0.775 |
| AFR | 11.93(8.21–15.93) | 13.09(10.20–17.62) | 8.14(6.84–11.29) | 7.16(5.12–10.04) | <0.001 | <0.001 | 0.171 |
| D-dimer (µg/mL) | 0.33(0.20–0.60) | 0.27(0.18–0.46) | 0.55(0.29–1.12) | 2.47(1.26–3.56) | <0.001 | <0.001 | 0.004 |
| Biochemical test | |||||||
| Lactate dehydrogenase(U/L) | 216.0(183.5–282.0) | 204.0(176.5–230.5) | 273.0(236.3–356.0) | 377(336.0–691.0) | <0.001 | <0.001 | 0.017 |
| Urea (mmol/L) | 4.10(3.20–5.20) | 3.90(3.00–4.80) | 4.90(4.05–6.13) | 7.20(2.90–15.80) | 0.002 | 0.022 | 0.132 |
| Creatine kinase (U/L) | 85.0(60.0–130.0) | 81.0(58.5–122.0) | 111.0(70.0–194.0) | 61.00(23.0–160.0) | 0.025 | 0.477 | 0.136 |
| High-sensitive cardiac troponin I(ng/mL) | 7.96(5.81–10.11) | 6.89(4.99–9.19) | 10.20(8.12–13.41) | 10.59(7.03–38.30) | <0.001 | 0.009 | 0.518 |
| Myoglobin (ng/mL) | 29.30(21.00–43.55) | 22.70(21.00–36.30) | 52.70(34.80–76.80) | 27.1(21.00–33.20) | <0.001 | 0.832 | 0.088 |
| ESR (mm/h) | 33.00(21.00–63.00) | 27.50(14.00–51.25) | 63.00(28.50–99.25) | 59.5(41.75–101.5) | <0.001 | 0.012 | 0.864 |
| C-reactive protein (mg/L) | 13.03(2.81–49.73) | 7.77(1.56–23.56) | 46.8(18.1–105.5) | 111.3(87.1–155.3) | <0.001 | <0.001 | 0.026 |
| Procalcitonin (ng/mL) | 0.04(0.02–0.08) | 0.03(0.02–0.05) | 0.07(0.05–011) | 0.17(0.13–0.21) | <0.001 | <0.001 | 0.004 |
| Lymphocyte subgroup | |||||||
| CD3 Lymphocyte (per µL) | 560.0(363.0–898.3) | 696.5(497–1022.8) | 333.5(155.0–505.3) | 189(104.8–433.8) | <0.001 | <0.001 | 0.183 |
| CD3+ CD4+ Lymphocyte (per µL) | 364.5(208.8–539.0) | 413.5(283.3–617.5) | 207.0(102.5–301.0) | 133.0(69.0–204.3) | <0.001 | <0.001 | 0.209 |
| CD3+ CD8+ Lymphocyte (per µL) | 184.5(104.0–291.3) | 230.0(136.5–344.3) | 101.0(53.5–169.25) | 43.0(34.0–118.8) | <0.001 | 0.001 | 0.133 |
| CD56+CD16+ Lymphocyte (per µL) | 109.5(72.8–176.25) | 142.0(87.8–192.5) | 76.0(53.0–103.25) | 81.0(51.75–95.25) | <0.001 | 0.004 | 0.970 |
| CD19+ Lymphocyte(per µL) | 106.0(69.50–173.0) | 127.0(83.0–210.25) | 69.0(40.5–108.5) | 71.5(32.9–107.75) | <0.001 | 0.016 | 0.985 |
| CD3+CD4+CD25+CD127+ Lymphocyte (per µL) | 32.37(17.10–58.35) | 44.18(29.16–72.08) | 21.60(10.54–33.75) | 10.61(4.50–13.07) | <0.001 | 0.003 | 0.047 |
| Cytokine | |||||||
| IL-2r | 508.0(408.3–611.0) | 471.5(400.8–577.8) | 689.0(518.5–780.5) | NA | 0.006 | NA | NA |
| IL-6 | 5.67(2.55–12.05) | 4.57(2.46–10.50) | 10.13(2.41–26.74) | 33.0(12.56–94.41) | 0.077 | 0.005 | 0.053 |
| IL-10 | 2.36(1.50–4.26) | 1.78(1.26–2.47) | 3.41(1.72–4.77) | 5.80(4.21–10.84) | 0.036 | 0.005 | 0.066 |
Abbreviations: AFR, albumin/fibrinogen ratio; PLR, Platelet/lymphocyte ratio; NLR, neutrophil-to-lymphocyte ratio; LMR, lymphocyte/monocyte ratio; ESR, erythrocyte sedimentation rate; IL-2r, interleukin-2 receptor; IL-6, interleukin-6; IL-10, interleukin-10; N, non-severe; S, Severe; C, Critical; NA, not available.