Table 3.
Univariate and Multivariate Logistic Analyses of Risk Factors for Severe Group
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Sex(male) | 1.155 (0.711–4.308) | 0.223 | - | - |
| Age(years)* | 1.065(1.029–1.102) | <0.001 | - | - |
| Body mass index(kg/m2)* | 1.051(0.924–1.195) | 0.452 | - | - |
| Alcohol(yes) | 2.040(0.456–9.135) | 0.351 | - | - |
| Hypertension(yes) | 3.583(0.834–15.397) | 0.086 | - | - |
| Diabetes(yes) | 1.680(0.392–7.206) | 0.485 | - | - |
| Time from onset to admission(days)* | 1.155(1.017–1.312) | 0.026 | - | - |
| White blood cell count(×109 per L)* | 1.164(1.003–1.352) | 0.046 | - | - |
| Neutrophil granulocyte(×109 per L)* | 1.302(1.096–1.547) | 0.003 | - | - |
| Lymphocyte count(×109 per L)* | 0.016(0.003–0.097) | <0.001 | - | - |
| CD3 Lymphocyte(>473 per µL) | 0.101(0.037–0.272) | <0.001 | - | - |
| CD3+ CD4+ Lymphocyte(>268 per µL) | 0.091(0.034–0.244) | <0.001 | - | - |
| CD3+ CD8+ Lymphocyte(>174 per µL) | 0.132(0.048–0.361) | <0.001 | - | - |
| CD56+CD16+ Lymphocyte(>83 per µL) | 0.125(0.049–0.324) | <0.000 | - | - |
| CD19+ Lymphocyte(>116 per µL) | 0.120(0.038–0.376) | <0.001 | 0.190(0.040–0.911) | 0.038 |
| CD3+CD4+CD25+CD127+Lymphocyte(>24 per µL) | 0.077(0.022–0.276) | <0.001 | - | - |
| Platelet count(>150×109 per L) | 0.273(0.113–0.659) | 0.004 | - | - |
| C-reactive protein(>17.6 mg/L) | 10.733(3.693–31.199) | <0.001 | - | - |
| D-Dimer(>0.48 mg/L) | 7.100(2.801–17.997) | <0.001 | - | - |
| ESR(>62.5 mm/h) | 7.897(3.049–20.454) | <0.001 | - | - |
| Procalcitonin(>0.04 ng/mL) | 8.653(2.980–25.124) | <0.001 | - | - |
| High-sensitive troponin T(>8.8 pg/mL) | 6.400(2.497–16.404) | <0.001 | - | - |
| Creatine kinase(>97.5 U/L) | 3.343(1.364–8.193) | 0.008 | - | - |
| Creatine kinase-MB(>15.5 U/L) | 4.286(1.658–11.078) | 0.003 | - | - |
| Myoglobin(>36.8 ng/mL) | 9.693(3.352–28.029) | <0.001 | 5.645(1.373–23.206) | 0.016 |
| Lactate dehydrogenase(>244 U/L) | 11.211(4.149–30.290) | <0.001 | 4.829(1.233–18.911) | 0.024 |
| Creatinine(>52.3 µmol/L) | 5.319(1.149–24.623) | 0.033 | - | - |
| Urea(>4.4 mmol/L) | 4.472(1.604–12.472) | 0.004 | - | - |
| IL-2r(>615 U/mL) | 18.667(3.390–102.772) | 0.001 | - | - |
| IL-6(>12.25 pg/mL) | 4.431(1.505–13.048) | 0.007 | - | - |
| IL-1β(>11.8 pg/mL) | 1.894(0.713–5.034) | 0.200 | ||
| IL-2(>1.99pg/mL) | 2.000(0.430–9.293 | 0.376 | ||
| IL-4(>1.31pg/mL) | 6.000(1.052–34.212) | 0.044 | ||
| IL-5(>1.86 pg/mL) | 7.467(1.385–40.245) | 0.019 | ||
| IL-8(>20.5 pg/mL) | 0.390(0.079–1.931) | 0.248 | ||
| IL-10(>2.82 pg/mL) | 9.000(1.550–52.266) | 0.014 | ||
| IL-17(>1.48 pg/mL) | 9.917(1.747–56.304) | 0.010 | ||
| IL-12p70(>0.52 pg/mL) | 4.667(0.916–23.785) | 0.064 | ||
| IFN-α(>1.98 pg/mL) | 4.400(0.749–25.842) | 0.101 | ||
| IFN-γ(>1.41 pg/mL) | 0.167(0.029–0.950) | 0.044 | ||
| TNF(>2.58 pg/mL) | 6.750(0.719–63.372) | 0.095 | ||
| Albumin(>40.2 g/L) | 0.062(0.020–0.188) | <0.001 | - | - |
| Fibrinogen(>4.3 g/L) | 7.283(2.855–18.577) | <0.001 | - | - |
| PLR(>165.9) | 5.252(1.941–14.214) | 0.001 | - | - |
| NLR(>6.31) | 11.857(4.069–34.551) | <0.001 | - | - |
| LMR(>3.41) | 0.190(0.066–0.547) | 0.002 | - | - |
| AFR (>11.67) | 0.105(0.036–0.304) | <0.001 | 0.116(0.026–0.512) | 0.005 |
Note: *Per 1 unit increase.
Abbreviations: OR, Odd ratio; CI, confidence interval; AFR, albumin/fibrinogen ratio; PLR, Platelet/lymphocyte ratio; NLR, Neutrophil granulocyte/lymphocyte ratio; LMR, lymphocyte/monocyte ratio; ESR, erythrocyte sedimentation rate; IL-2r, interleukin-2 receptor; IL-6, interleukin-6; IL-1β, interleukin-1β; IL-2, interleukin-2; IL4, interleukin-4; IL-5, interleukin-5; IL-8, interleukin-8; IL-10, interleukin-10; IL-17, interleukin-17; IL-12p70, interleukin-12p70; IFN-α, interferon-α; IFN-γ, interferon-γ; TNF, Tumor Necrosis Factor.