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. 2024 Jul 1;20(11):2540–2555. doi: 10.1080/15548627.2024.2368335

Figure 1.

Figure 1.

Inactivation of ATG7 in adult mice. (A) Schematic representation of creation of atg7iKO mice. (B-E) Forebrains of Control (Ctrl) or atg7iKO mice 3.5 or 6.5 wks after tam injection (+tam) were homogenized and subjected to quantitative western blot and probed for (B and C) ATG7 and (D and E) SQSTM1/p62. (F and G) Quantitative immunoblot analyses against MAP1LC3/LC3 or SQSTM1/p62 of synaptosomal fractions from mouse forebrain. VCL was used as a loading control. Ctrl, n = 3; atg7iKO(3.5), n = 4; atg7iKO(6.5), n = 4. Statistical analyses are found in Table S1. *p < 0.05, **p < 0.01, ***p < 0.001.