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. 2024 Nov 14;10(1):2419779. doi: 10.1080/20565623.2024.2419779

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© 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 4. — Time-course changes in each biomarker regarding the efficacy of HDM SLIT in patients with AD with allergic rhinitis.

(A, B, D–G) Changes in each biomarker from baseline to 12 and 24 months after the start of HDM SLIT. (C) Changes in each biomarker from baseline to 12 months after the start of HDM SLIT. (H & I) Changes in the surface marker ratio in the basophil activation test from baseline to 12 and 24 months after the start of HDM SLIT. To calculate the responsiveness of basophils, we divided the antigen stimulation MFI by the anti-IgE stimulation MFI and presented it as the ‘CD203c ratio’ or ‘CD63 ratio’.

Der p s-IgE: Dermatophagoides pteronyssinus specific-IgE; Der p s-IgG4: Dermatophagoides pteronyssinus specific-IgG4; Der f s-IgE: Dermatophagoides farinae specific-IgE; Der f s-IgG4: Dermatophagoides farinae specific-IgG4; IgE: Immunoglobulin E; IgG4: Immunoglobulin G subclass 4; TARC: Thymus and activation-regulated chemokine.