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Preservation of oRPs in chaperone-regulated condensates. The ribosome biogenesis cycle is disrupted during stress, resulting in the formation of oRP condensates at the nucleolar periphery, the reversibility of which is maintained by the activity of Hsp70 and Sis1. Even solid oRP condensates are reversible if Sis1 and Hsp70 are allowed to resume their activity. NPC, nuclear pore complex; RPG, ribosomal protein gene.
