Table 1.
Baseline characteristics of the patients, n (%)
|
Characteristics
|
Organoid culture successful (n = 9)
|
Organoid culture unsuccessful (n = 6)
|
P value
|
| Sex (male) | 6 (66.7) | 3 (50.0) | 0.622 |
| Age (year), mean ± SD | 60.3 ± 3.5 | 69.6 ± 5.4 | 0.088 |
| BMI, mean ± SD | 22.7 ± 1.3 | 21.6 ± 1.3 | 0.361 |
| Smoking | 3 (33.3) | 1 (17.7) | 0.604 |
| Drinking | 3 (33.3) | 1 (17.7) | 0.604 |
| Tumor size (cm), mean ± SD | 4.2 ± 0.6 | 3.4 ± 0.3 | 0.159 |
| Tumor volume (cm3), mean ± SD | 72.4 ± 24.1 | 29.4 ± 8.8 | 0.085 |
| Hypertension | 1 (11.1) | 2 (33.3) | 0.525 |
| Diabetes | 4 (66.7) | 1 (16.7) | 0.580 |
| Family of history malignancy | 3 (33.3) | 0 (0) | 0.229 |
| Personal of history malignancy | 1 (11.1) | 0 (0) | 1.000 |
| History of abdominal operation | 1 (11.1) | 1 (16.7) | 1.000 |
| Location, head-neck | 5 (55.6) | 4 (66.7) | 0.608 |
| Clinical TNM staging, III/IV | 7 (77.8) | 6 (100.0) | 0.622 |
| T stage, T3-T4 | 6 (66.7) | 5 (83.3) | 0.245 |
| N stage, N1 | 7 (87.5) | 4 (66.7) | 0.538 |
| M stage, M1 | 4 (44.4) | 3 (50.5) | 1.000 |
| CA19-9 (U/mL), mean ± SD | 774.4 ± 299.4 | 1098.6 ± 382.7 | 0.349 |
| CA125, mean ± SD | 34.9 ± 11.5 | 55.3 ± 16.6 | 0.514 |
| CEA, mean ± SD | 4.7 ± 1.1 | 4.1 ± 0.7 | 0.372 |
| Time from initial diagnosis to puncture biopsy (month), mean ± SD | 2.5 ± 0.8 | 1.0 ± 0.1 | 0.526 |
| Ki-67 (%), mean ± SD | 28.9 ± 7.2 | 18.0 ± 3.7 | 0.264 |
| IHC, CA19-9 (+) | 7 (100.0) | 5 (83.3) | |
| IHC, CEA (+) | 5 (83.3) | 4 (100.0) | 1.000 |
| IHC, P53 (+) | 5 (71.4) | 3 (60.0) | 1.000 |
BMI: Body mass index; TNM: Tumor node metastasis; CA: Carbohydrate antigen; CEA: Carcinoembryonic antigen; IHC: Immunohistochemistry.